Megacraspedus laseni sp. nov. is described from Dolomiti Bellunesi (Veneto Region, Prov. Belluno, Italy). The habitus of the adult and male genitalia are described and illustrated whereas the female sex remains unknown. The new species belongs to the Megacraspedus pentheres species group and is closely related to the southern alpine M. eburnellus Huemer Karsholt, 2001 from which it differs in morphological characters and in DNA barcode sequence. Megacraspedus carolustertius Gastón Vives, 2020 is synonymized with M. quadristictus Lhomme, 1946, syn. nov.
Keywords: Lepidoptera, Alps, Belluno, Anomologinae, morphology, DNA barcoding, new species, new synonymy.