Do we cause false positives? An experimental series on droplet or airborne SARS-CoV-2 contamination of sampling tubes during swab collection in a test center

Antimicrob Resist Infect Control. 2021 Mar 9;10(1):51. doi: 10.1186/s13756-021-00920-z.

Abstract

The rapid spread of the coronavirus disease 2019 pandemic urged immense testing capacities as one cornerstone of infection control. Many institutions opened outpatient SARS-CoV-2 test centers to allow large number of tests in comparatively short time frames. With increasing positive test rates, concerns for a possible airborne or droplet contamination of specimens leading to false-positive results were raised. In our experimental series performed in a dedicated SARS-CoV-2 test center, 40 open collection tubes placed for defined time periods in proximity to individuals were found to be SARS-CoV-2 negative. These findings argue against false-positive SARS-CoV-2 results due to droplet or airborne contamination.

Keywords: COVID-19; Contamination; False-positive test results; SARS-CoV-2.

MeSH terms

  • COVID-19 / diagnosis*
  • COVID-19 Testing / methods*
  • Equipment Contamination / statistics & numerical data*
  • False Positive Reactions
  • Humans
  • Particulate Matter / analysis
  • Polymerase Chain Reaction
  • SARS-CoV-2 / isolation & purification
  • Specimen Handling / methods*

Substances

  • Particulate Matter