Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties

Albert Gyapong Aduhene; Hongliang Cui; Hongyi Yang; Chengwei Liu; Guangchao Sui; Changli Liu

doi:10.3389/fbioe.2021.646995

Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties

Front Bioeng Biotechnol. 2021 Mar 4:9:646995. doi: 10.3389/fbioe.2021.646995. eCollection 2021.

Authors

Albert Gyapong Aduhene^{1

2}, Hongliang Cui^{1

2}, Hongyi Yang², Chengwei Liu², Guangchao Sui², Changli Liu^{1

2}

Affiliations

¹ Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
² College of Life Sciences, Northeast Forestry University, Harbin, China.

Abstract

Many single-use non-degradable plastics are a threat to life today, and several polyhydroxyalkanoates (PHAs) biopolymers have been developed in the bioplastic industry to place petrochemical-based plastics. One of such is the novel biomaterial poly(3-hydroxypropionate) [poly(3HP)] because of its biocompatibility, biodegradability, and high yield synthesis using engineered strains. To date, many bio-polymer-based functional composites have been developed to increase the value of raw microbial-biopolymers obtained from cheap sources. This review article broadly covers poly(3HP), a comprehensive summary of critical biosynthetic production pathways comparing the yields and titers achieved in different Microbial cell Factories. This article also provides extensive knowledge and highlights recent progress on biosensors' use to optimize poly(3HP) production, some bacteria host adopted for production, chemical and physical properties, life cycle assessment for poly(3HP) production using corn oil as carbon source, and some essential medical applications of poly(3HP).

Keywords: biosynthesis; cell factory; life cycle assessment; malonyl-CoA biosensor; material/physical property; poly(3-hydroxypropionate).

Publication types

Review