In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

Ulises Ahumada-Castro; Galdo Bustos; Eduardo Silva-Pavez; Andrea Puebla-Huerta; Alenka Lovy; César Cárdenas

doi:10.3389/fcell.2021.629522

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca²⁺ Fluxes

Front Cell Dev Biol. 2021 Mar 2:9:629522. doi: 10.3389/fcell.2021.629522. eCollection 2021.

Authors

Ulises Ahumada-Castro¹, Galdo Bustos¹, Eduardo Silva-Pavez¹, Andrea Puebla-Huerta¹, Alenka Lovy^{1

2}, César Cárdenas^{1

3

4}

Affiliations

¹ Geroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.
² Department of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, MA, United States.
³ Buck Institute for Research on Aging, Novato, CA, United States.
⁴ Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.

Abstract

In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca²⁺) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca²⁺ communication on organelle function as well as catabolism and anabolism, particularly in cancer.

Keywords: IP3Rs; calcium; endoplasmic reticulum; inositol triphosphate (IP3) receptors; lysosome; metabolism; mitochondria.

Publication types

Review