Metabolizer phenotype prediction in different Peruvian ethnic groups through CYP2C9 polymorphisms

Edward Valencia Ayala; Mylenka Chevarría Arriaga; Eduardo Barbosa Coelho; José Sandoval Sandoval; Alberto Salazar Granara

doi:10.1515/dmpt-2020-0146

Metabolizer phenotype prediction in different Peruvian ethnic groups through CYP2C9 polymorphisms

Drug Metab Pers Ther. 2021 Mar 18. doi: 10.1515/dmpt-2020-0146. Online ahead of print.

Authors

Edward Valencia Ayala^{1

2}, Mylenka Chevarría Arriaga², Eduardo Barbosa Coelho³, José Sandoval Sandoval⁴, Alberto Salazar Granara^{2

5}

Affiliations

¹ Facultad de Medicina Humana, Universidad de San Martin de Porres, Centro de Investigación en Infectología e Inmunología-Instituto de Investigación, La Molina, Lima, Peru.
² Facultad de Medicina Humana, Universidad de San Martin de Porres, Centro de Investigación de Medicina Tradicional y Farmacología-Instituto de Investigación, La Molina, Lima, Peru.
³ Departamento de Clínica Médica, Disciplina de Nefrologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, Brazil.
⁴ Facultad de Medicina Humana, Universidad de San Martin de Porres, Centro de Investigación en Genética y Biología Molecular-Instituto de Investigación, La Molina, Lima, Peru.
⁵ Facultad de Medicina Humana, Universidad de San Martin de Porres, Centro de Investigación de Medicina de Altura-Instituto de Investigación, La Molina, Lima, Peru.

PMID: 33735946
DOI: 10.1515/dmpt-2020-0146

Abstract

Objectives: The CYP2C9 gene have three common alleles, CYP2C9*1, CYP2C9*2 and CYP2C9*3, associated with different homozygous (*1/*1, *2/*2 and *3/*3) and heterozygous (*1/*2 and *1/*3) genotypes, which in turn are related to extensive (gEM), intermediate (gIM) and poor (gPM) metabolizers. Likewise, the inter-ethnic variability was intimately associated with different drug metabolism. Therefore, the aim of the present study was predict the metabolizer phenotypes in different Peruvian ethnic groups from lowland (<2,500 m) and highland (>2,500 m).

Methods: TaqMan genotyping assays were performed in a group of 174 healthy unrelated Peruvian individuals.

Results: In this study, the allelic comparison between the three eco-regions showed that the CYP2C9*1 was the most common in Andean (96.32%); the *2 was the most frequent in Coast (7.45%, p<0.05). Regarding the *3 was the most common in Amazonian (6.25%, p<0.05). In a corroborative manner, the gEM was the most common in Andean (94.74%), the gIM in Coast (17.02%) and gPM in Amazonian (6.25%) populations.

Conclusions: Our study provides a valuable source of information about to metabolizer phenotype drugs in different Peruvian ethnic groups. In this way, it could be established suitable genetic-dosage medicaments for various common diseases in these heterogenetic populations.

Keywords: allelic variants; ethnic population; genotyping; metabolizer phenotype.