Purpose The purpose of this study was to investigate the effectiveness of verbal-gestural treatment on verb production in patients with acute aphasia. Method Treatment was delivered during inpatient stay to four participants using a single-subject design. Results All patients demonstrated improvements in verbal expression. Some patients' improvements generalized to untrained verbs and nouns. Conclusions This study indicates verbal-gestural treatment can be an effective treatment model for acute aphasia in a hospital environment. Concurrent deficits resulting from stroke may impact the success with verbal-gestural treatment at this acute phase of recovery.