Kidney involvement in coronavirus-associated diseases (Review)

Exp Ther Med. 2021 Apr;21(4):361. doi: 10.3892/etm.2021.9792. Epub 2021 Feb 13.

Abstract

Since 2003, coronaviruses have caused multiple global pandemic diseases, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19). Clinical and autopsy findings suggest that the occurrence of kidney injury during infection may negatively affect the clinical outcomes of infected patients. The authoritative model predicts that outbreaks of other novel coronavirus pneumonias will continue to threaten human health in the future. The aim of the present systematic review was to summarize the basic knowledge of coronavirus, coronavirus infection-associated kidney injury and the corresponding therapies, in order to provide new insights for clinicians to better understand the kidney involvement of coronavirus so that more effective therapeutic strategies can be employed against coronavirus infection in the future.

Keywords: Middle East respiratory syndrome; coronavirus; coronavirus disease 2019; kidney injury; severe acute respiratory syndrome.

Publication types

  • Review

Grants and funding

Funding: The present study was supported by the National Natural Sciences Foundation of China (grant nos. 81870498 and 81900633) and the National Natural Sciences Foundation of Hunan Province (grant no. 2017JJ2342).