Construction of cancer-on-a-chip for drug screening

Yan Liu; Qingzhen Yang; Hui Zhang; Shuang Han; Na Liu; Hui Ren; Hui Guo; Feng Xu

doi:10.1016/j.drudis.2021.03.006

Construction of cancer-on-a-chip for drug screening

Drug Discov Today. 2021 Aug;26(8):1875-1890. doi: 10.1016/j.drudis.2021.03.006. Epub 2021 Mar 14.

Authors

Yan Liu¹, Qingzhen Yang¹, Hui Zhang², Shuang Han³, Na Liu⁴, Hui Ren⁵, Hui Guo⁶, Feng Xu⁷

Affiliations

¹ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
² The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, P.R. China.
³ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Honghui Hospital, Xi'an, Shaanxi 710049, China.
⁴ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710004, China.
⁵ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China. Electronic address: renhui@xjtufh.edu.cn.
⁶ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Oncology Department, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. Electronic address: guohuihappy97@163.com.
⁷ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. Electronic address: fengxu@mail.xjtu.edu.cn.

PMID: 33731317
DOI: 10.1016/j.drudis.2021.03.006

Abstract

Cancer-on-a-chip has effectively contributed to the development of drug screening, holding great promise for more convenient and reliable drug development as well as personalized drug administration.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Drug Development / methods
High-Throughput Screening Assays
Humans
Lab-On-A-Chip Devices*
Neoplasms / drug therapy*
Tumor Microenvironment

Substances

Antineoplastic Agents