Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis

Yeon-Woo Kang; Subin Park; Kun-Joo Lee; Dain Moon; Young-Min Kim; Seung-Woo Lee

doi:10.4110/in.2021.21.e1

Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis

Immune Netw. 2021 Feb 26;21(1):e1. doi: 10.4110/in.2021.21.e1. eCollection 2021 Feb.

Authors

Yeon-Woo Kang¹, Subin Park¹, Kun-Joo Lee¹, Dain Moon¹, Young-Min Kim², Seung-Woo Lee¹

Affiliations

¹ Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
² Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Abstract

The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune responses against SARS-CoV-2 and its relationship with the coronavirus disease 2019 (COVID-19) pathogenesis will be the sole basis for developing and applying therapeutics. This review will summarize the published results that relate to innate immune responses against infections with human coronaviruses including SARS-CoV-1 and SARS-CoV-2 in both humans and animal models. The topics encompass the innate immune sensing of the virus to the dysregulation of various innate immune cells during infection and disease progression.

Keywords: COVID-19; Coronavirus; Innate immunity; SARS-CoV-2.

Publication types

Review