Nanoparticle-Based Activatable Probes for Bioimaging

Tiancong Ma; Tian Xia

doi:10.1002/adbi.202000193

Nanoparticle-Based Activatable Probes for Bioimaging

Adv Biol (Weinh). 2021 Jan;5(1):e2000193. doi: 10.1002/adbi.202000193. Epub 2021 Jan 4.

Authors

Tiancong Ma^{1

2}, Tian Xia¹

Affiliations

¹ Division of Nanomedicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1772, USA.
² Department of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, 90095-1772, USA.

Abstract

Molecular imaging can provide functional and molecular information at the cellular or subcellular level in vivo in a noninvasive manner. Activatable nanoprobes that can react to the surrounding physiological environment or biomarkers are appealing agents to improve the efficacy, specificity, and sensitivity of molecular imaging. The physiological parameters, including redox status, pH, presence of enzymes, and hypoxia, can be designed as the stimuli of the activatable probes. However, the success rate of imaging nanoprobes for clinical translation is low. Herein, the recent advances in nanoparticle-based activatable imaging probes are critically reviewed. In addition, the challenges for clinical translation of these nanoprobes are also discussed in this review.

Keywords: activatable nanoprobes; clinical translation; molecular imaging; nanomaterials; theranostics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorescent Dyes*
Molecular Imaging
Nanoparticles*
Oxidation-Reduction

Substances

Fluorescent Dyes

Abstract

Publication types

MeSH terms

Substances

Grants and funding