Influence of ventilation inhomogeneity on diffusing capacity of carbon monoxide in smokers without COPD

Johanna Manuela Kurz; Jeannette Frey; Reto Auer; Nicolas Rodondi; Sylvia Nyilas; Nikolay Pavlov; Manuela Funke-Chambour; Florian Singer

doi:10.1183/23120541.00706-2020

Influence of ventilation inhomogeneity on diffusing capacity of carbon monoxide in smokers without COPD

ERJ Open Res. 2021 Mar 8;7(1):00706-2020. doi: 10.1183/23120541.00706-2020. eCollection 2021 Jan.

Authors

Johanna Manuela Kurz^{1

2}, Jeannette Frey³, Reto Auer^{4

5}, Nicolas Rodondi^{4

6}, Sylvia Nyilas⁷, Nikolay Pavlov³, Manuela Funke-Chambour^{3

8}, Florian Singer^{1

8}

Affiliations

¹ Division of Respiratory Medicine, Dept of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
² Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
³ Dept of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
⁵ University General Medicine and Public Health Centre, University of Lausanne, Lausanne, Switzerland.
⁶ Dept of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁷ Dept of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
⁸ These authors contributed equally.

Abstract

In smokers with preserved spirometry, D _LCO is associated with ventilation inhomogeneity arising from peripheral airways. Measurement of D _LCO to screen for early lung function abnormalities in smokers may be suboptimal and could be replaced by MBW. https://bit.ly/3nLmgg1.