FIB-4 Improves LSM-Based Prediction of Complications in Overweight or Obese Patients With Compensated Advanced Chronic Liver Disease

Yuly P Mendoza; Mohamed Shengir; Jaime Bosch; Giada Sebastiani; Annalisa Berzigotti

doi:10.1016/j.cgh.2021.03.007

FIB-4 Improves LSM-Based Prediction of Complications in Overweight or Obese Patients With Compensated Advanced Chronic Liver Disease

Clin Gastroenterol Hepatol. 2022 Oct;20(10):2396-2398.e3. doi: 10.1016/j.cgh.2021.03.007. Epub 2021 Mar 11.

Authors

Yuly P Mendoza¹, Mohamed Shengir², Jaime Bosch³, Giada Sebastiani⁴, Annalisa Berzigotti⁵

Affiliations

¹ University Clinic for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
² Division of Experimental Medicine, McGill University, Montreal, Canada.
³ August Pi i Sunyer Biomedical Research Institute, Biomedical Research Networking Center in Hepatic and Digestive Diseases, Hospital Clínic, University of Barcelona, Barcelona, Spain; Hepatology Group, Department of Biomedical Research, University of Bern, Bern, Switzerland.
⁴ Division of Experimental Medicine, McGill University, Montreal, Canada; Division of Gastroenterology and Hepatology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada.
⁵ University Clinic for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland; Hepatology Group, Department of Biomedical Research, University of Bern, Bern, Switzerland. Electronic address: annalisa.berzigotti@insel.ch.

PMID: 33716139
DOI: 10.1016/j.cgh.2021.03.007

Abstract

Liver stiffness measurement (LSM) by transient elastography (TE) is able to stratify the risk of decompensation in patients with compensated advanced chronic liver disease (cACLD).¹ Recently, we demonstrated that this holds true also in overweight or obese patients with cACLD due to nonalcoholic steatohepatitis (NASH) studied by the XL probe. An LSM cutoff of ≥21 kPa remained associated with a high risk of complications in this population.².

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Elasticity Imaging Techniques*
Humans
Liver / diagnostic imaging
Liver / pathology
Liver Cirrhosis / complications
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / pathology
Obesity / complications
Obesity / pathology
Overweight / complications
Overweight / pathology