Elimination of Senescent Endothelial Cells: Good or Bad Idea?

Abstract

Cellular senescence has a critical role in many physiopathological contexts. Recent studies highlight the beneficial and adverse effects that eliminating senescent endothelial cells can have on health span, questioning the current development of drugs that induce the death of senescent cells, named senolytics, as a therapeutic strategy.

Keywords: cellular senescence; endothelial cells; health span; senolytics.