Intelligent wound patches have the potential properties of ultra-adhesion, self-healing ability, biosensing, antibacterial, anti-inflammatory, etc. In situ sensing (biosensing and monitoring) and intelligent drug delivery deserve more exploration, and new strategies of these two factors are of great importance. In this Feature, a comprehensive set of the progress in the area of intelligent wound patches, especially those based on multiple biosensing and electronics, and their potentials in drug release is deliberated. In addition, the major challenges in this field and opinions on its future developments are portrayed.