ABCC3 and GSTM5 gene polymorphisms affect overall survival in Polish acute myeloid leukaemia patients

Curr Probl Cancer. 2021 Oct;45(5):100729. doi: 10.1016/j.currproblcancer.2021.100729. Epub 2021 Mar 6.

Abstract

Acute myeloid leukaemia (AML) is a very heterogeneous malignancy in which standard treatment is based on chemotherapy. Resistance to chemotherapeutic agents remains a big problem in AML, because negatively influences patient overall survival. Several resistance mechanisms have been described, the best of which is the process of drug removal from the cell and/or nucleus by membrane transport proteins. The aim of the study was to investigate the effect of polymorphism of genes coding ABCC3, GSTM5 involved in the transport and metabolism of drugs. For this purpose 95 newly diagnosed AML patients and 125 healthy controls were genotyped. We showed that ABCC3 rs4148405 and GSTM5 rs3754446, but not ABCC33 rs4793665, affected overall survival in Polish AML patients.

Keywords: ABCC3; Acute myeloid leukaemia; GSTM5; Gene polymorphisms; Overall survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Disease-Free Survival
  • Female
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Leukemia, Myeloid, Acute / epidemiology*
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Middle Aged
  • Poland / epidemiology
  • Polymorphism, Single Nucleotide
  • Survival Rate
  • Young Adult

Substances

  • ABCA3 protein, human
  • ATP-Binding Cassette Transporters
  • GSTM5 protein, human
  • Glutathione Transferase