Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole

Bioorg Med Chem Lett. 2021 May 15:40:127944. doi: 10.1016/j.bmcl.2021.127944. Epub 2021 Mar 11.

Abstract

Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.

Keywords: Antifungal activity; Hybrids; Lipophilicity; Solubility; Thiazolo-pyrimidins; Triazole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / pharmacology*
  • Drug Design
  • Fungi / drug effects
  • Microbial Sensitivity Tests
  • Pyrimidines / chemical synthesis
  • Pyrimidines / pharmacology*
  • Solubility
  • Thiazoles / chemical synthesis
  • Thiazoles / pharmacology*
  • Triazoles / chemical synthesis
  • Triazoles / pharmacology*

Substances

  • Antifungal Agents
  • Pyrimidines
  • Thiazoles
  • Triazoles