Diffusion-Weighted Imaging Reflects Tumor Grading and Microvascular Invasion in Hepatocellular Carcinoma

Alexey Surov; Maciej Pech; Jazan Omari; Frank Fischbach; Robert Damm; Katharina Fischbach; Maciej Powerski; Borna Relja; Andreas Wienke

doi:10.1159/000511384

Diffusion-Weighted Imaging Reflects Tumor Grading and Microvascular Invasion in Hepatocellular Carcinoma

Liver Cancer. 2021 Feb;10(1):10-24. doi: 10.1159/000511384. Epub 2021 Jan 27.

Authors

Alexey Surov¹, Maciej Pech¹, Jazan Omari¹, Frank Fischbach¹, Robert Damm¹, Katharina Fischbach¹, Maciej Powerski¹, Borna Relja¹, Andreas Wienke²

Affiliations

¹ Department of Radiology and Nuclear Medicine University of Magdeburg, Magdeburg, Germany.
² Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Abstract

Background: To date, there are inconsistent data about relationships between diffusion-weighted imaging (DWI) and tumor grading/microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Our purpose was to systematize the reported results regarding the role of DWI in prediction of tumor grading/MVI in HCC.

Method: MEDLINE library, Scopus, and Embase data bases were screened up to December 2019. Overall, 29 studies with 2,715 tumors were included into the analysis. There were 20 studies regarding DWI and tumor grading, 8 studies about DWI and MVI, and 1 study investigated DWI, tumor grading, and MVI in HCC.

Results: In 21 studies (1,799 tumors), mean apparent diffusion coefficient (ADC) values (ADC_mean) were used for distinguishing HCCs. ADC_mean of G1-3 lesions overlapped significantly. In 4 studies (461 lesions), minimum ADC (ADC_min) was used. ADC_min values in G1/2 lesions were over 0.80 × 10^-3 mm²/s and in G3 tumors below 0.80 × 10^-3 mm²/s. In 4 studies (241 tumors), true diffusion (D) was reported. A significant overlapping of D values between G1, G2, and G3 groups was found. ADC_mean and MVI were analyzed in 9 studies (1,059 HCCs). ADC_mean values of MIV+/MVI- lesions overlapped significantly. ADC_min was used in 4 studies (672 lesions). ADC_min values of MVI+ tumors were in the area under 1.00 × 10^-3 mm²/s. In 3 studies (227 tumors), D was used. Also, D values of MVI+ lesions were predominantly in the area under 1.00 × 10^-3 mm²/s.

Conclusion: ADC_min reflects tumor grading, and ADC_min and D predict MVI in HCC. Therefore, these DWI parameters should be estimated for every HCC lesion for pretreatment tumor stratification. ADC_mean cannot predict tumor grading/MVI in HCC.

Keywords: Diffusion-weighted imaging; Grading; Hepatocellular carcinoma; Microvascular invasion.

Publication types

Review