Review of operative considerations in spinal cord stem cell therapy

Pavan S Upadhyayula; Joel R Martin; Robert C Rennert; Joseph D Ciacci

doi:10.4252/wjsc.v13.i2.168

Review of operative considerations in spinal cord stem cell therapy

World J Stem Cells. 2021 Feb 26;13(2):168-176. doi: 10.4252/wjsc.v13.i2.168.

Authors

Pavan S Upadhyayula¹, Joel R Martin², Robert C Rennert², Joseph D Ciacci²

Affiliations

¹ Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, United States. psupadhy@health.ucsd.edu.
² Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, United States.

Abstract

Spinal cord injury (SCI) can permanently impair motor and sensory function and has a devastating cost to patients and the United States healthcare system. Stem cell transplantation for treatment of SCI is a new technique aimed at creating biological functional recovery. Operative techniques in stem cell transplantation for SCI are varied. We review various clinical treatment paradigms, surgical techniques and technical considerations important in SCI treatment. The NCBI PubMed database was queried for "SCI" and "stem cell" with a filter placed for "clinical trials". Thirty-nine articles resulted from the search and 29 were included and evaluated by study authors. A total of 10 articles were excluded (9 not SCI focused or transplantation focused, 1 canine model). Key considerations for stem cell transplantation include method of delivery (intravenous, intrathecal, intramedullary, or excision and engraftment), time course of treatment, number of treatments and time from injury until treatment. There are no phase III clinical trials yet, but decreased time from injury to treatment and a greater number of stem cell injections both seem to increase the chance of functional recovery.

Keywords: Intramedullary; Operative techniques; Spinal cord injury; Stem cell; Stem cell transplantation.

Publication types

Review