Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Nat Commun. 2021 Mar 11;12(1):1588. doi: 10.1038/s41467-021-21826-9.

Abstract

Adipose tissue expansion, as seen in obesity, is often metabolically detrimental causing insulin resistance and the metabolic syndrome. However, white adipose tissue expansion at early ages is essential to establish a functional metabolism. To understand the differences between adolescent and adult adipose tissue expansion, we studied the cellular composition of the stromal vascular fraction of subcutaneous adipose tissue of two and eight weeks old mice using single cell RNA sequencing. We identified a subset of adolescent preadipocytes expressing the mature white adipocyte marker Asc-1 that showed a low ability to differentiate into beige adipocytes compared to Asc-1 negative cells in vitro. Loss of Asc-1 in subcutaneous preadipocytes resulted in spontaneous differentiation of beige adipocytes in vitro and in vivo. Mechanistically, this was mediated by a function of the amino acid transporter ASC-1 specifically in proliferating preadipocytes involving the intracellular accumulation of the ASC-1 cargo D-serine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes, Beige / cytology
  • Adipocytes, Beige / metabolism*
  • Adipocytes, White / cytology
  • Adipocytes, White / metabolism*
  • Adipose Tissue, Beige / cytology
  • Adipose Tissue, Beige / growth & development*
  • Adipose Tissue, White / cytology
  • Adipose Tissue, White / growth & development*
  • Amino Acid Transport System y+ / genetics
  • Amino Acid Transport System y+ / metabolism*
  • Animals
  • Base Sequence
  • Cell Differentiation / genetics
  • Cells, Cultured
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Sequence Analysis, RNA
  • Single-Cell Analysis
  • Uncoupling Protein 1 / biosynthesis

Substances

  • Amino Acid Transport System y+
  • Slc7a10 protein, mouse
  • Ucp1 protein, mouse
  • Uncoupling Protein 1