SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response

Guijie Guo; Ming Gao; Xiaochen Gao; Bibo Zhu; Jinzhou Huang; Kuntian Luo; Yong Zhang; Jie Sun; Min Deng; Zhenkun Lou

doi:10.1038/s41392-021-00509-3

SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response

Signal Transduct Target Ther. 2021 Mar 11;6(1):119. doi: 10.1038/s41392-021-00509-3.

Authors

Guijie Guo^#^{1

2}, Ming Gao^#^{1

2}, Xiaochen Gao^{3

4}, Bibo Zhu^{3

4}, Jinzhou Huang^{1

2}, Kuntian Luo^{1

2}, Yong Zhang^{1

2}, Jie Sun^{3

4}, Min Deng^{1

2}, Zhenkun Lou^{5

6}

Affiliations

¹ Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
² Department of Oncology, Mayo Clinic, Rochester, MN, USA.
³ Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
⁴ Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
⁵ Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. lou.zhenkun@mayo.edu.
⁶ Department of Oncology, Mayo Clinic, Rochester, MN, USA. lou.zhenkun@mayo.edu.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
COVID-19 / genetics
COVID-19 / immunology*
COVID-19 / pathology
HEK293 Cells
Humans
Immunity, Innate*
SARS-CoV-2 / genetics
SARS-CoV-2 / immunology*
Ubiquitin-Specific Proteases / genetics
Ubiquitin-Specific Proteases / immunology*
Viral Nonstructural Proteins / genetics
Viral Nonstructural Proteins / immunology*

Substances

Viral Nonstructural Proteins
USP13 protein, human
Ubiquitin-Specific Proteases

Publication types

MeSH terms

Substances

Grants and funding