Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation

Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):2033-2036. doi: 10.1007/s10096-021-04186-6. Epub 2021 Mar 10.

Abstract

Nocardiosis is a life-threatening opportunistic infection in immunocompromised patients. Herein, we present successful adjunctive use of liposomal nebulized amikacin and tedizolid in a recipient of allogeneic hematopoietic stem cell transplantation infected with Nocardia nova complex who presented multiple complications to conventional therapeutic options.

Keywords: Allogeneic hematopoietic stem cell transplantation; Liposomal nebulized amikacin; Nocardiosis; Tedizolid.

Publication types

  • Case Reports

MeSH terms

  • Amikacin / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Liposomes / administration & dosage*
  • Liposomes / chemistry
  • Liposomes / therapeutic use
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers
  • Nocardia / drug effects*
  • Nocardia Infections / diagnosis
  • Nocardia Infections / drug therapy*
  • Oxazolidinones / pharmacology*
  • Tetrazoles / pharmacology*
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Immunosuppressive Agents
  • Liposomes
  • Oxazolidinones
  • Tetrazoles
  • Amikacin
  • tedizolid

Supplementary concepts

  • Nocardia nova