This research was conducted to analyze the compatibility of used monomers and produce the high functional POSS-based ophthalmic polymer containing silicone monomers and neodymium nanoparticle. Synthesized silicone polymer (SiD), trimethylsilylmethacrylate (TSMA), N-vinyl-2-pyrrolidone (NVP) and neodymium nanoparticles were used as additives for the basic combination of polyhedral oligomeric silsesquioxane (POSS), and methyl methacrylate (DMA). And also, the materials were copolymerized with ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, azobisisobutyronitrile (AIBN) as the initiator. It is judged that the POSS-co-NVP polymer is optically good and thus have good compatibility. Especially copolymerization with TSMA showed high oxygen permeability, but with SID considered to be more stable judging by lens shape. Physical properties shows that the neodymium nanoparticle increases the wettability while maintaining water content. These materials are considered to make synergy effect each other, so it can be used in functional hydrogel ophthalmic lenses.