Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation

Natasha Lopes Fischer; Sunny Shin; Igor E Brodsky

doi:10.1016/j.celrep.2021.108855

Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation

Cell Rep. 2021 Mar 9;34(10):108855. doi: 10.1016/j.celrep.2021.108855.

Authors

Natasha Lopes Fischer¹, Sunny Shin¹, Igor E Brodsky²

Affiliations

¹ Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
² Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: ibrodsky@vet.upenn.edu.

PMID: 33691120
DOI: 10.1016/j.celrep.2021.108855

Abstract

Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death.

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MeSH terms

Humans
Inflammasomes*
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein*
Succinates

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Succinates
itaconic acid