A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

Jane E Sinclair; Yanshan Zhu; Gang Xu; Wei Ma; Haiyan Shi; Kun-Long Ma; Chun-Feng Cao; Ling-Xi Kong; Ke-Qiang Wan; Juan Liao; Hai-Qiang Wang; Matt Arentz; Meredith A Redd; Linda A Gallo; Kirsty R Short

doi:10.1016/j.isci.2021.102264

A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

iScience. 2021 Apr 23;24(4):102264. doi: 10.1016/j.isci.2021.102264. Epub 2021 Mar 5.

Authors

Jane E Sinclair¹, Yanshan Zhu¹, Gang Xu², Wei Ma^{3

4}, Haiyan Shi⁵, Kun-Long Ma⁶, Chun-Feng Cao⁶, Ling-Xi Kong⁶, Ke-Qiang Wan⁶, Juan Liao⁶, Hai-Qiang Wang⁷, Matt Arentz⁸, Meredith A Redd⁹, Linda A Gallo¹⁰, Kirsty R Short^{1

11}

Affiliations

¹ School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
² Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
³ Department of Geriatric Medicine, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
⁴ School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
⁵ Department of Respiratory Medicine, Guangzhou Eighth People's Hospital, Guangzhou, Guangdong, China.
⁶ Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China.
⁷ Institute of Integrative Medicine, Shaanxi University of Chinese Medicine, Xi'an Shaanxi Province, China.
⁸ Department of Global Health, University of Washington, Seattle, WA, USA.
⁹ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
¹⁰ School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.
¹¹ School of Public Health, The University of Queensland, Brisbane, Australia.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.

Keywords: Omics; Virology.