The identification, development and therapeutic potential of IL-10-producing regulatory B cells in multiple sclerosis

Weiwei Xiang; Chong Xie; Yangtai Guan

doi:10.1016/j.jneuroim.2021.577520

The identification, development and therapeutic potential of IL-10-producing regulatory B cells in multiple sclerosis

J Neuroimmunol. 2021 May 15:354:577520. doi: 10.1016/j.jneuroim.2021.577520. Epub 2021 Feb 27.

Authors

Weiwei Xiang¹, Chong Xie¹, Yangtai Guan²

Affiliations

¹ Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Rd, Shanghai 200127, China.
² Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Rd, Shanghai 200127, China. Electronic address: yangtaiguan@sina.com.

PMID: 33684831
DOI: 10.1016/j.jneuroim.2021.577520

Abstract

Regulatory B cells are a rare B-cell subset widely known to exert their immunosuppressive function via the production of interleukin-10 (IL-10) and other mechanisms. B10 cells are a special subset of regulatory B cells with immunoregulatory function that is fully attributed to IL-10. Their unique roles in the animal model of multiple sclerosis (MS) have been described, as well as their relevance in MS patients. This review specifically focuses on the identification and development of B10 cells, the signals that promote IL-10 production in B cells, the roles of B10 cells in MS, and the potential and major challenges of the application of B10-based therapies for MS.

Keywords: B10 cells; Interleukin-10; Multiple sclerosis; Regulatory B cells; Therapeutic strategy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
B-Lymphocytes, Regulatory / immunology*
Humans
Immunotherapy / methods
Interleukin-10 / immunology*
Multiple Sclerosis / immunology*

Substances

Interleukin-10