Effect of Dexmedetomidine Hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis

Yong-Hui Liu; Ye Zhao; Xiang-Yang Wang; Hong-Xun Cui

doi:10.12669/pjms.37.2.2383

Effect of Dexmedetomidine Hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis

Pak J Med Sci. 2021 Mar-Apr;37(2):520-524. doi: 10.12669/pjms.37.2.2383.

Authors

Yong-Hui Liu¹, Ye Zhao², Xiang-Yang Wang³, Hong-Xun Cui⁴

Affiliations

¹ Yong-hui Liu, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
² Ye Zhao, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
³ Xiang-yang Wang, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
⁴ Hong-xun Cui, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.

Abstract

Objective: To explore the effect of dexmedetomidine hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis.

Method: A double-blind control observation was conducted in spinal tuberculosis patients with the use of general anesthesia during the operation. A total of 171 spinal tuberculosis patients who received endotracheal intubation for general anesthesia in Henan University of Chinese Medicine from January 2017 to April 2019 were included. The concentration changes in serum TNF-α and IL-6 were recorded at one hour, six hour and one day after the operation. The incidence of postoperative pulmonary complications of patients were also evaluated.

Results: The results showed that in the experimental group compared with the control group, serum TNF-α and IL-6 concentrations one hour, six hour and one day after the operation were significantly lower (P<0.05). The rate of postoperative pulmonary complications was lower in the experimental group than that in the control group (P<0.05).

Conclusion: Dexmedetomidine hydrochloride has obvious anti-inflammatory effects and can reduce the incidence of pulmonary complications after surgery.

Keywords: Dexmedetomidine hydrochloride; Inflammatory factor; Perioperative period; Spinal tuberculosis.