Drug-Drug Interactions at Organic Cation Transporter 1

Shiwei Zhou; Sujuan Zeng; Yan Shu

doi:10.3389/fphar.2021.628705

Drug-Drug Interactions at Organic Cation Transporter 1

Front Pharmacol. 2021 Feb 17:12:628705. doi: 10.3389/fphar.2021.628705. eCollection 2021.

Authors

Shiwei Zhou^{1

2

3}, Sujuan Zeng¹, Yan Shu^{1

2}

Affiliations

¹ Key Laboratory of Oral Medicine, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.
² Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD, United States.
³ Department of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Hunan, China.

Abstract

The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.

Keywords: OCT1; drug-drug interaction; inhibitor; organic cation transporters; substrate.

Publication types

Review