Tailored treatment to MRD response: A phase I/II study for newly diagnosed multiple myeloma patients using high dose twice-weekly carfilzomib (45 and 56 mg/m2 ) in combination with lenalidomide and dexamethasone

Am J Hematol. 2021 Jun 1;96(6):E193-E196. doi: 10.1002/ajh.26150. Epub 2021 Mar 19.
No abstract available

Publication types

  • Clinical Trial, Phase I
  • Clinical Trial, Phase II
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Clinical Decision-Making
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects
  • Female
  • Gastrointestinal Diseases / chemically induced
  • Heart Diseases / chemically induced
  • Hematologic Diseases / chemically induced
  • Humans
  • Lenalidomide / administration & dosage
  • Lenalidomide / adverse effects
  • Male
  • Middle Aged
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / pathology
  • Neoplasm, Residual
  • Oligopeptides / administration & dosage
  • Oligopeptides / adverse effects
  • Progression-Free Survival
  • Proof of Concept Study

Substances

  • Oligopeptides
  • carfilzomib
  • Dexamethasone
  • Lenalidomide