The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients

William G Dunn; Muxin S Gu; Margarete A Fabre; Jonathan Cooper; Josep F Nomdedeu; Laura Koumas; Katerina Nicolaou; Jiangxiang Chi; Paul Costeas; George S Vassiliou

doi:10.1007/s00277-021-04472-5

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients

Ann Hematol. 2022 Feb;101(2):443-445. doi: 10.1007/s00277-021-04472-5. Epub 2021 Mar 1.

Authors

William G Dunn^{1

2}, Muxin S Gu^{1

3}, Margarete A Fabre^{1

2

3}, Jonathan Cooper^{1

3}, Josep F Nomdedeu^{1

3

4}, Laura Koumas⁵, Katerina Nicolaou⁵, Jiangxiang Chi⁵, Paul Costeas^{6

7}, George S Vassiliou^{8

9

10

11

12}

Affiliations

¹ Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK.
² Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.
³ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
⁴ Department of Haematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
⁵ Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus.
⁶ Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus. paul.costeas@karaiskakio.org.cy.
⁷ Cyprus Cancer Research Institute, Nicosia, Cyprus. paul.costeas@karaiskakio.org.cy.
⁸ Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK. gsv20@sanger.ac.uk.
⁹ Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK. gsv20@sanger.ac.uk.
¹⁰ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. gsv20@sanger.ac.uk.
¹¹ Center for the Study of Haematological Malignancies, Karaiskakio Foundation, Nicosia, Cyprus. gsv20@sanger.ac.uk.
¹² Cyprus Cancer Research Institute, Nicosia, Cyprus. gsv20@sanger.ac.uk.

No abstract available

Publication types

Letter

MeSH terms

Adult
Blood Preservation
DNA / blood
DNA / genetics
Humans
Leukemia, Promyelocytic, Acute / blood*
Leukemia, Promyelocytic, Acute / genetics
Middle Aged
Oncogene Proteins, Fusion / blood*
Oncogene Proteins, Fusion / genetics
Whole Genome Sequencing

Substances

Oncogene Proteins, Fusion
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
DNA

Publication types

MeSH terms

Substances

Grants and funding