When Should We Expect Curative Results of Neoadjuvant Treatment in Locally Advanced Rectal Cancer Patients?

Mihai-Teodor Georgescu; Traian Patrascu; Luiza Georgia Serbanescu; Rodica Maricela Anghel; Laurentia Nicoleta Gales; Florin Teodor Georgescu; Radu Iulian Mitrica; Dragos Eugen Georgescu

doi:10.21614/chirurgia.116.1.16

When Should We Expect Curative Results of Neoadjuvant Treatment in Locally Advanced Rectal Cancer Patients?

Chirurgia (Bucur). 2021 Jan-Feb;116(1):16-23. doi: 10.21614/chirurgia.116.1.16.

Authors

Mihai-Teodor Georgescu, Traian Patrascu, Luiza Georgia Serbanescu, Rodica Maricela Anghel, Laurentia Nicoleta Gales, Florin Teodor Georgescu, Radu Iulian Mitrica, Dragos Eugen Georgescu

PMID: 33638322
DOI: 10.21614/chirurgia.116.1.16

Abstract

This review on recently published literature aims to summarize published data on pathologic complete response following neoadjuvant treatment in biopsy proven locally advanced rectal cancer patients. Published articles referring to pCR rectal cancer patients were identified using PubMed search. Eleven relevant articles were selected, based on tumor, treatment, and patient characteristics reporting. As a conclusion, rectal cancer patients with the highest chances of complete clinical or pathological response to neoadjuvant treatment are males, who are around 60 years, diagnosed with well or moderate differentiated locally advanced rectal cancer.

Keywords: chemoradiotherapy; completeresponse; neoadjuvant; rectum.

Celsius.

Publication types

Review

MeSH terms

Biopsy
Humans
Neoadjuvant Therapy*
Neoplasm Staging
Rectal Neoplasms* / pathology
Rectal Neoplasms* / therapy
Rectum / pathology
Rectum / surgery
Treatment Outcome