Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment

Li Li; Yujin Qian; Luyao Sun; Felicity Y Han; Run Zhang; Peng-Yuan Wang; Zhi Ping Xu

doi:10.1016/j.nano.2021.102369

Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment

Nanomedicine. 2021 Jun:34:102369. doi: 10.1016/j.nano.2021.102369. Epub 2021 Feb 24.

Authors

Li Li¹, Yujin Qian², Luyao Sun², Felicity Y Han³, Run Zhang², Peng-Yuan Wang⁴, Zhi Ping Xu⁵

Affiliations

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia. Electronic address: l.li2@uq.edu.au.
² Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
³ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
⁴ Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia.
⁵ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia. Electronic address: gordonxu@uq.edu.au.

PMID: 33636347
DOI: 10.1016/j.nano.2021.102369

Abstract

Combination chemotherapy with two or more complimentary drugs has been widely used for clinical cancer treatment. However, the efficacy and side effects of combination chemotherapy still remain a challenge. Here, we constructed an albumin-stabilized layered double hydroxide nanoparticle (BLDH) system to simultaneously load and deliver two widely used anti-tumor drugs, i.e. 5-fluorouracil (5FU) and albumin-bound PTX (Abraxane, ABX) for colorectal cancer treatment. The cellular uptake test has revealed that 5FU-ABX encapsulated BLDH (BLDH/5FU-ABX) nanoparticles were efficiently internalized by the colorectal cancer cell (HCT-116), synergistically inducing apoptosis of colon cancer cells. The in vivo test has demonstrated that BLDH/5FU-ABX nanomedicine significantly inhibited the tumor growth after three intravenous injections, without any detectable side effects. The enhanced therapeutic effectiveness is attributed to efficient accumulation of BLDH/5FU-ABX at tumor sites and acid-sensitive release of co-loaded drugs. Thus, combination chemotherapy based on BLDH/5FU-ABX nanomedicine would be a new strategy for colorectal cancer treatment.

Keywords: Albumin-stabilized layered double hydroxide nanoparticles; Colorectal cancer treatment; Combination chemotherapy; Nanomedicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albumin-Bound Paclitaxel / administration & dosage
Albumin-Bound Paclitaxel / therapeutic use
Albumins / chemistry*
Animals
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Colorectal Neoplasms / drug therapy*
Drug Synergism
Female
Fluorouracil / administration & dosage
Fluorouracil / therapeutic use
HCT116 Cells
Humans
Hydroxides / chemistry*
Injections, Intravenous
Mice
Mice, Inbred BALB C
Mice, Nude
Nanomedicine*
Nanoparticles / chemistry*
Xenograft Model Antitumor Assays

Substances

Albumin-Bound Paclitaxel
Albumins
Hydroxides
Fluorouracil