Rapid effects of neurosteroids on neuronal plasticity and their physiological and pathological implications

Abstract

Current neuroscience research on neurosteroids and their synthetic analogues - neuroactive steroids - clearly demonstrate their drug likeness in a variety of neurological and psychiatric conditions. Moreover, research on neurosteroids continues to provide novel mechanistic insights into receptor activation or inhibition of various receptors. This mini-review will provide a high-level overview of the research area and discuss the various classes of potential physiological and pathological implications discovered so far.

Keywords: Drug development; Ligand-gated ion channel; Neuroactive steroids; Neurosteroids; Steroid.