The acute effects of alcohol on state rumination in the laboratory

Psychopharmacology (Berl). 2021 Jun;238(6):1671-1686. doi: 10.1007/s00213-021-05802-1. Epub 2021 Feb 26.

Abstract

Rationale: Rumination is a repetitive, negative, self-focused thinking style associated with various forms of psychopathology. Recent studies suggest that rumination increases craving for alcohol and predicts harmful drinking and alcohol-related problems. However, the acute effects of alcohol on rumination have not been previously studied. It is proposed that alcohol may reduce ruminative thinking through decreasing negative mood.

Objectives: In the present study, we aimed to test the previously unexplored effects of acute alcohol consumption on rumination in a hazardous drinking population.

Methods: We conducted a randomised placebo-controlled laboratory study to examine the effect of low (0.4 g kg-1) and high doses (0.8 g kg-1) of alcohol on state rumination compared to placebo. Participants completed a rumination induction task prior to receiving drinks. We then measured state rumination and mood at repeated time points; 30 min, 60 min and 90 min post-drinks consumption.

Results: We found a significant decrease in state rumination in the low-dose alcohol group compared to placebo at 30 min post-alcohol consumption, but no difference was observed between the high-dose alcohol and placebo groups. Mediation analysis provided evidence for an indirect effect of alcohol on state rumination through concurrent changes in negative mood.

Conclusions: These findings suggest that acute alcohol consumption can regulate negative mood and concurrently rumination, providing preliminary evidence for the role of rumination in alcohol use disorders. Rumination may be a treatment target in alcohol use disorders.

Keywords: Alcohol use disorders; Depression; Negative affect; Rumination.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Affect
  • Alcohol Drinking / psychology*
  • Alcohol-Related Disorders / psychology*
  • Alcoholism / psychology*
  • Child
  • Cognition / drug effects
  • Double-Blind Method
  • Female
  • Humans
  • Laboratories
  • Male
  • Pilot Projects
  • Young Adult