Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein

Clin Transl Med. 2021 Feb;11(2):e281. doi: 10.1002/ctm2.281.

Satish Sagar¹, Ashok Kumar Rathinavel¹, William E Lutz¹, Lucas R Struble¹, Surender Khurana², Andy T Schnaubelt³, Nitish Kumar Mishra⁴, Chittibabu Guda^{4

5}, Nicholas Y Palermo⁶, Mara J Broadhurst³, Tobias Hoffmann⁷, Kenneth W Bayles³, St Patrick M Reid³, Gloria E O Borgstahl^{1

5}, Prakash Radhakrishnan^{1

3

4

5}

¹ Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
² Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, Maryland, USA.
³ Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁴ Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁵ Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁶ Computational Chemistry Core, University of Nebraska Medical Center, Omaha, Nebraska, USA.
⁷ Advanced Light and Electron Microscopy, Centre for Biological Threats and Special Pathogens 4 (ZBS 4), Robert Koch Institute, Berlin, Germany.

No abstract available

Publication types