At present, effective antibiotics and comprehensive symptomatic/supportive treatment as early as possible are mainly used for the treatment of severe pertussis in clinical practice. However, some children with severe pertussis have unsatisfactory response to commonly used drugs and treatment measures in the intensive care unit and thus have a high risk of death. Studies have shown that certain treatment measures given in the early stage, such as exchange transfusion, may help reduce deaths, but there is still a lack of uniform implementation norms. How to determine the treatment regimen for severe pertussis and improve treatment ability remains a difficult issue in clinical practice. This article reviews the advances in the treatment of severe pertussis, in order to provide a reference for clinical treatment and research.
对于重症百日咳，目前临床上主要采用尽早使用敏感抗生素、综合性的对症支持治疗。但部分重症患儿对常用药物及重症监护室常见救治措施的治疗反应不理想，死亡风险大。研究提示如果早期实施某些治疗措施，如换血治疗等可减少死亡，但仍缺乏统一的实施规范。如何确定重症百日咳的治疗方案，提高临床救治能力仍然是一个棘手的问题。现对重症百日咳的治疗进展进行综述，旨在为临床治疗实践和研究提供参考。