De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot

Laura Díaz-Casado; Israel Serrano-Chacón; Laura Montalvillo-Jiménez; Francisco Corzana; Agatha Bastida; Andrés G Santana; Carlos González; Juan Luis Asensio

doi:10.1002/chem.202100456

De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot

Chemistry. 2021 Apr 7;27(20):6106. doi: 10.1002/chem.202100456. Epub 2021 Feb 22.

Authors

Laura Díaz-Casado¹, Israel Serrano-Chacón², Laura Montalvillo-Jiménez¹, Francisco Corzana³, Agatha Bastida¹, Andrés G Santana¹, Carlos González², Juan Luis Asensio¹

Affiliations

¹ Glycochemistry and Molecular Recognition group-Dpt. Bio-Organic Chemistry, Instituto de Química Orgánica General (IQOG-CSIC), Juan de la Cierva 3., 28006, Madrid, Spain.
² Instituto de Química-Física Rocasolano (IQFR-CSIC), Serrano 119., 28006, Madrid, Spain.
³ Department of Chemistry, Centro de Investigación en Síntesis Química, Universidad de La Rioja, Madre de Dios, 53., 26006, Logroño, Spain.

PMID: 33615580
DOI: 10.1002/chem.202100456

Abstract

Invited for the cover of this issue are Andrés G. Santana, Carlos González, Juan Luis Asensio and co-workers at Instituto de Química Orgánica General, Instituto de Química-Física Rocasolano and Universidad de La Rioja. The image depicts drug selectivity using a metaphor of an arrow hitting a target. Read the full text of the article at 10.1002/chem.202005026.