Turning off the alarm - Targeting alarmins and other epithelial mediators of allergic inflammation with biologics

Melanie Albrecht

doi:10.5414/ALX02194E

Turning off the alarm - Targeting alarmins and other epithelial mediators of allergic inflammation with biologics

Allergol Select. 2021 Feb 9:5:82-88. doi: 10.5414/ALX02194E. eCollection 2021.

Author

Melanie Albrecht¹

Affiliation

¹ Molecular Allergology/Research Group of the Vice President, Paul Ehrlich Institute, Langen, Germany.

Abstract

Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators have been identified that are secreted by epithelial cells and act upstream in the cascade of allergic inflammation. Such are the alarmin IL-33 as well as TSLP and IL-5. The role of each cytokine in sensitization and effector phase of allergic inflammation and how development of biologics is ongoing in order to inhibit this pathomechanism will be described in the following article.

Keywords: IL-25; IL-33; TSLP; alarmins; allergic inflammation; biologics; epithelial cytokines.

Publication types

Review