Factors and potential treatments of cough after pulmonary resection: A systematic review

Xin Li; Xizhe Li; Wuyang Zhang; Qi Liu; Yang Gao; Ruimin Chang; Chunfang Zhang

doi:10.1016/j.asjsur.2021.01.001

Factors and potential treatments of cough after pulmonary resection: A systematic review

Asian J Surg. 2021 Aug;44(8):1029-1036. doi: 10.1016/j.asjsur.2021.01.001. Epub 2021 Feb 17.

Authors

Xin Li¹, Xizhe Li², Wuyang Zhang³, Qi Liu⁴, Yang Gao⁵, Ruimin Chang⁶, Chunfang Zhang⁷

Affiliations

¹ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: 18220180190@163.com.
² Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: lixizhezy@sina.com.
³ Clinical Skills Training Center, XiangyaHospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: yueyexingzhu@163.com.
⁴ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: LQ6903215216@qq.com.
⁵ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: gaoyang_george@sina.com.
⁶ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, 410008, Hunan, China. Electronic address: changruimin@csu.edu.cn.
⁷ Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China; Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Changsha, 410008, Hunan, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address: zhcf3801@csu.edu.cn.

PMID: 33610443
DOI: 10.1016/j.asjsur.2021.01.001

Abstract

Cough is a common complication following pulmonary resection. Persistent and severe cough after pulmonary resection can cause significant impairments in quality of life among postoperative patients. Complications of cough can be life-threatening. To improve patients' probability and quality of life, factors that induce cough after pulmonary resection (CAP) and potential treatments should be explored and summarized. Previous studies have identified various factors related to CAP. However, those factors have not been categorized and analyzed in a sensible manner. Here, we summarized the different factors and classified them into four groups. Potential therapies might be developed to selectively target different factors that affect CAP. However, the exact mechanism underlying CAP remains unknown, making it difficult to treat and manage CAP. In this review, we summarized the latest studies in our understanding of the factors related to CAP and potential treatments targeting those factors. This review can help understand the mechanism of CAP and develop efficient therapies and management.

Keywords: Cough after pulmonary resection; Surgical; Systematic review; Therapeutics.

Publication types

Review
Systematic Review

MeSH terms

Cough* / etiology
Humans
Quality of Life*