Calcific aortic valve disease: turning therapeutic discovery up a notch

Nat Rev Cardiol. 2021 May;18(5):309-310. doi: 10.1038/s41569-021-00528-1.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aortic Valve / pathology*
  • Aortic Valve / physiopathology
  • Aortic Valve Stenosis* / drug therapy
  • Aortic Valve Stenosis* / genetics
  • Aortic Valve Stenosis* / physiopathology
  • Calcinosis* / drug therapy
  • Calcinosis* / genetics
  • Calcinosis* / physiopathology
  • Cardiovascular Agents / pharmacology*
  • Cardiovascular Agents / therapeutic use
  • ERRalpha Estrogen-Related Receptor
  • Endothelial Cells / drug effects
  • Gene Regulatory Networks
  • Humans
  • Induced Pluripotent Stem Cells / drug effects
  • Machine Learning*
  • Nitriles / pharmacology*
  • Nitriles / therapeutic use
  • Receptor, Notch1 / genetics*
  • Receptors, Estrogen / antagonists & inhibitors
  • Thiazoles / pharmacology*
  • Thiazoles / therapeutic use

Substances

  • Cardiovascular Agents
  • NOTCH1 protein, human
  • Nitriles
  • Notch1 protein, mouse
  • Receptor, Notch1
  • Receptors, Estrogen
  • Thiazoles
  • XCT790

Supplementary concepts

  • Aortic Valve, Calcification of