The dural sinus hub: more than just a brain drain

Sarah Mundt; Annika Keller; Melanie Greter

doi:10.1016/j.cell.2021.01.040

The dural sinus hub: more than just a brain drain

Cell. 2021 Feb 18;184(4):858-860. doi: 10.1016/j.cell.2021.01.040.

Authors

Sarah Mundt¹, Annika Keller², Melanie Greter³

Affiliations

¹ Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
² Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, 8952 Schlieren, Switzerland.
³ Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland. Electronic address: greter@immunology.uzh.ch.

PMID: 33606985
DOI: 10.1016/j.cell.2021.01.040

Abstract

Recent findings of an active neuroimmune exchange at brain border regions have challenged the concept of the immune-privileged central nervous system. The study by Rustenhoven et al. in this issue of Cell shows that dural sinuses serve as a conduit for brain-derived antigens to interact with the immune system, allowing in situ immune surveillance.

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MeSH terms

Brain*
Cranial Sinuses*
Humans