Non-human primates and Leishmania immunity

Sonia André; Vasco Rodrigues; Morgane Picard; Ricardo Silvestre; Jérôme Estaquier

doi:10.1016/j.cytox.2020.100038

Non-human primates and Leishmania immunity

Cytokine X. 2020 Oct 12;2(4):100038. doi: 10.1016/j.cytox.2020.100038. eCollection 2020 Dec.

Authors

Sonia André¹, Vasco Rodrigues¹, Morgane Picard¹, Ricardo Silvestre^{2

3}, Jérôme Estaquier^{1

4}

Affiliations

¹ INSERM-U1124, Paris University, Paris, France.
² ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
³ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
⁴ Centre de Recherche du CHU de Québec, Laval University, QC, Quebec, Canada.

Abstract

In the context of infectious diseases, non-human primates (NHP) provide the best animal models of human diseases due to the close phylogenetic relationship and the similar physiology and anatomical systems. Herein, we summarized the contribution of NHP models for understanding the immunity to leishmaniases, which are a group of diseases caused by infection with protozoan parasites of the genus Leishmania and classified as one of the neglected tropical diseases.

Keywords: CXCR5; Cytokines; Immunity; Leishmania; Monkeys; T cells; Tfh.