Herpes simplex virus-2 associated with a large fungating penile mass

Max S Bowman; Ursula E Lang; Kieron S Leslie; Gregory Amend; Benjamin N Breyer

doi:10.1016/j.eucr.2021.101594

Herpes simplex virus-2 associated with a large fungating penile mass

Urol Case Rep. 2021 Feb 4:36:101594. doi: 10.1016/j.eucr.2021.101594. eCollection 2021 May.

Authors

Max S Bowman¹, Ursula E Lang², Kieron S Leslie³, Gregory Amend¹, Benjamin N Breyer⁴

Affiliations

¹ Department of Urology, University of California, San Francisco, Department of Urology, 400 Parnassus Ave, San Francisco, CA, 94143, USA.
² Department of Pathology, Zuckerberg San Francisco General Hospital and University of California, San Francisco, 1001 Potrero Ave, San Francisco, CA, 94110, USA.
³ Department of Dermatology, Zuckerberg San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA, 94110, USA.
⁴ Department of Urology, Zuckerberg San Francisco General Hospital and University of California, San Francisco 400 Parnassus Ave, San Francisco, CA, 94143, USA.

Abstract

A 48-year-old male with HIV/AIDS presented with an enlarging nodular lesion on the base of his penis. Histology revealed changes consistent with chronic viral infection and culture grew herpes simplex virus 2 (HSV-2). The lesion was refractory to valacyclovir and intralesional (IL) cidofovir therapy. Urology excised the mass and the defect was repaired primarily with good cosmetic result. Post-operative pathology confirmed HSV-2 despite the unusual appearance of the lesion consisting of nodular mass without gross ulceration.

Keywords: Genital lesion; HIV; Herpes; Infectious disease; Reconstructive urology.

Publication types

Case Reports