Impact of insomnia and obstructive sleep apnea on the risk of acute exacerbation of chronic obstructive pulmonary disease

Shi Qi Li; Xian Wen Sun; Liu Zhang; Yong Jie Ding; Hong Peng Li; Ya Ru Yan; Ying Ni Lin; Jian Ping Zhou; Qing Yun Li

doi:10.1016/j.smrv.2021.101444

Impact of insomnia and obstructive sleep apnea on the risk of acute exacerbation of chronic obstructive pulmonary disease

Sleep Med Rev. 2021 Aug:58:101444. doi: 10.1016/j.smrv.2021.101444. Epub 2021 Jan 29.

Authors

Shi Qi Li¹, Xian Wen Sun¹, Liu Zhang¹, Yong Jie Ding¹, Hong Peng Li¹, Ya Ru Yan¹, Ying Ni Lin¹, Jian Ping Zhou¹, Qing Yun Li²

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Institute of Respiratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
² Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Institute of Respiratory Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: liqingyun68@hotmail.com.

PMID: 33601330
DOI: 10.1016/j.smrv.2021.101444

Abstract

Chronic obstructive pulmonary disease (COPD) is a major health burden worldwide. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by worsening of patients' respiratory symptoms that requires a modification in medication. This event could accelerate disease progression and increase the risk of hospital admissions and mortality. Both insomnia and obstructive sleep apnea (OSA) are prevalent in patients with COPD, and are linked to increased susceptibility to AECOPD. Improper treatment of insomnia may increase the risk of adverse respiratory outcomes for patients with COPD, while effective continuous positive airway pressure (CPAP) treatment may reduce the risk of AECOPD and mortality in patients with overlap syndrome. Sleep disorders should be considered in clinical management for COPD.

Keywords: Chronic obstructive pulmonary disease; Exacerbation; Insomnia; Obstructive sleep apnea.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Continuous Positive Airway Pressure
Humans
Pulmonary Disease, Chronic Obstructive* / complications
Sleep Apnea, Obstructive* / complications
Sleep Apnea, Obstructive* / therapy
Sleep Initiation and Maintenance Disorders* / complications
Sleep Initiation and Maintenance Disorders* / therapy
Syndrome