Isolated bilateral congenital lacrimal gland agenesis-a case series

Nebras Alghazawi; Milad Modabber; Rami Darwich; Avi Saskin; Laura Russell; Christine Saint-Martin; Ayesha Khan

doi:10.1016/j.jaapos.2020.11.008

Isolated bilateral congenital lacrimal gland agenesis-a case series

J AAPOS. 2021 Apr;25(2):109-112.e1. doi: 10.1016/j.jaapos.2020.11.008. Epub 2021 Feb 16.

Authors

Nebras Alghazawi¹, Milad Modabber², Rami Darwich³, Avi Saskin⁴, Laura Russell⁴, Christine Saint-Martin⁵, Ayesha Khan⁶

Affiliations

¹ Faculty of Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.
² Department of Ophthalmology & Vision Science, UC Davis Eye Center, California. Electronic address: mmodabber@gmail.com.
³ Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
⁴ Division of Medical Genetics, Department of Medicine, McGill University, Montreal, Canada.
⁵ Department of Radiology, McGill University, Montreal, Quebec, Canada.
⁶ Department of Ophthalmology & Visual Sciences, McGill University, Montreal, Quebec, Canada.

PMID: 33601047
DOI: 10.1016/j.jaapos.2020.11.008

Abstract

We report 2 pediatric cases of isolated bilateral congenital lacrimal gland agenesis (CLGA). Patient 1 (1 year of age) and patient 2 (2 years of age) presented with symptoms of alacrimia and were diagnosed with bilateral isolated CLGA based on magnetic resonance imaging. Both patients were otherwise healthy, with no systemic associations. Molecular analysis for genetic causes of CLGA were negative. Both have been successfully medically managed.

MeSH terms

Child
Eye Abnormalities* / diagnostic imaging
Humans
Lacrimal Apparatus Diseases* / diagnostic imaging
Lacrimal Apparatus* / diagnostic imaging
Magnetic Resonance Imaging