Tensins - emerging insights into their domain functions, biological roles and disease relevance

J Cell Sci. 2021 Feb 17;134(4):jcs254029. doi: 10.1242/jcs.254029.

Abstract

Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well as mediating signal transduction pathways, leading to a variety of physiological processes, including cell proliferation, attachment, migration and mechanical sensing in a cell. Tensins are required for maintaining normal tissue structures and functions, especially in the kidney and heart, as well as in muscle regeneration, in animals. This Review discusses our current understanding of the domain functions and biological roles of tensins in cells and mice, as well as highlighting their relevance to human diseases.

Keywords: CTEN; Cancer; Cystic kidney; Focal adhesion; Mitral valve prolapse; Nephrotic syndrome; PTB; SH2; Tensin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Proliferation
  • Focal Adhesions* / metabolism
  • Mice
  • Signal Transduction*
  • Tensins / metabolism

Substances

  • Tensins
  • Tns2 protein, mouse