Coronavirus disease 2019 pandemic and alterations of body composition

Curr Opin Clin Nutr Metab Care. 2021 May 1;24(3):229-235. doi: 10.1097/MCO.0000000000000740.

Abstract

Purpose of review: This manuscript reviews evidence collected during COVID-19 pandemic and provides information on the impact of body composition on severity and outcomes of the disease, analysing methods used for body composition assessment. Malnutrition-screening tools will also be discussed to screen and diagnose the patients at higher risk of COVID-19 severity and related worse outcomes.

Recent findings: COVID-19 can occur in a wide range of presentation, from asymptomatic to severe forms. Among the major risk factors for worse severity, overnutrition, undernutrition and body composition play a role in the ability to respond to SARS-CoV-2 infection. Excess fat accumulation (i.e. obesity) or lean mass loss and functionality (i.e. sarcopenia) or a combination of both (i.e. sarcopenic obesity) can affect whole-body functioning. These body composition alterations in the short-term can influence susceptibility and immunological responses to the virus, inflammatory reaction, metabolic and respiratory distress, while in the long-term can modulate disease outcomes, namely length of stay, time required for recovery, risk of ICU-acquired weakness and long-term disabilities, and potentially increase the risk of death.

Summary: Individuals with malnutrition, sarcopenia, obesity, sarcopenic obesity and older adults with abnormal body composition or malnutrition risk may require tailored medical nutrition therapy to improve short and long-term COVID-19 outcomes.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Composition*
  • COVID-19 / complications
  • COVID-19 / physiopathology*
  • COVID-19 / virology
  • Female
  • Humans
  • Male
  • Malnutrition / physiopathology
  • Malnutrition / virology*
  • Middle Aged
  • Nutrition Therapy
  • Nutritional Status*
  • Obesity / physiopathology
  • Obesity / virology
  • Overnutrition / physiopathology
  • Overnutrition / virology
  • SARS-CoV-2*
  • Sarcopenia / physiopathology
  • Sarcopenia / virology
  • Severity of Illness Index