From the freezer to the clinic: Antifreeze proteins in the preservation of cells, tissues, and organs

Roderick P Tas; Vasco Sampaio-Pinto; Tom Wennekes; Linda W van Laake; Ilja K Voets

doi:10.15252/embr.202052162

From the freezer to the clinic: Antifreeze proteins in the preservation of cells, tissues, and organs

EMBO Rep. 2021 Mar 3;22(3):e52162. doi: 10.15252/embr.202052162. Epub 2021 Feb 15.

Authors

Roderick P Tas¹, Vasco Sampaio-Pinto^{2

3}, Tom Wennekes⁴, Linda W van Laake^{2

3}, Ilja K Voets¹

Affiliations

¹ Laboratory of Self-Organizing Soft Matter, Department of Chemical Engineering and Chemistry & Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology (TUE), Eindhoven, The Netherlands.
² Department of Cardiology and Experimental Cardiology Laboratory, University Medical Centre Utrecht, Utrecht, The Netherlands.
³ Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, The Netherlands.
⁴ Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.

Abstract

Understanding the mechanisms by which natural anti-freeze proteins protect cells and tissues from cold could help to improve the availability of donor organs for transplantation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifreeze Proteins*

Substances

Antifreeze Proteins

Grants and funding

635928/ERC_/European Research Council/International