Research Progress of Sirtuin4 in Cancer

Yibing Bai; Jiani Yang; Ying Cui; Yuanfei Yao; Feng Wu; Caiqi Liu; Xiaona Fan; Yanqiao Zhang

doi:10.3389/fonc.2020.562950

Research Progress of Sirtuin4 in Cancer

Front Oncol. 2021 Jan 8:10:562950. doi: 10.3389/fonc.2020.562950. eCollection 2020.

Authors

Yibing Bai^{1

2}, Jiani Yang^{1

2}, Ying Cui^{1

3}, Yuanfei Yao^{1

2}, Feng Wu⁴, Caiqi Liu¹, Xiaona Fan¹, Yanqiao Zhang^{1

2}

Affiliations

¹ Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
² Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China.
³ Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
⁴ Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Abstract

Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1-7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.

Keywords: cancer; enzymatic activities; localization; metabolism; mitochondria; sirtuin4; structure.

Publication types

Review