Targeting SHP2 as a therapeutic strategy for inflammatory diseases

Yang Liu; Xiaohe Yang; Yali Wang; Yueying Yang; Dejuan Sun; Hua Li; Lixia Chen

doi:10.1016/j.ejmech.2021.113264

Targeting SHP2 as a therapeutic strategy for inflammatory diseases

Eur J Med Chem. 2021 Mar 15:214:113264. doi: 10.1016/j.ejmech.2021.113264. Epub 2021 Feb 6.

Authors

Yang Liu¹, Xiaohe Yang¹, Yali Wang¹, Yueying Yang¹, Dejuan Sun², Hua Li³, Lixia Chen⁴

Affiliations

¹ Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
² Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: 760633805@qq.com.
³ Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: li_hua@hust.edu.cn.
⁴ Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com.

PMID: 33582386
DOI: 10.1016/j.ejmech.2021.113264

Abstract

With the change of lifestyle and the acceleration of aging process, inflammatory diseases have increasingly become one of the most vital threats to global human health. SHP2 protein is a non-receptor tyrosine phosphatase encoded by PTPN11 gene, and it is widely expressed in various tissues and cells. Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases. In this paper, the roles of SHP2 in inflammatory diseases of various physiological systems were reviewed. At the same time, the latest SHP2 inhibitors were summarized, which will hold a promise for the therapeutic potential in future.

Keywords: Cancer; Inflammation; SHP2; SHP2 inhibitors.

Publication types

Review

MeSH terms

Biological Products / chemistry
Biological Products / therapeutic use*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / therapeutic use*
Humans
Inflammation / drug therapy*
Inflammation / metabolism
Metabolic Diseases / drug therapy*
Metabolic Diseases / metabolism
Molecular Structure
Neurodegenerative Diseases / drug therapy*
Neurodegenerative Diseases / metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors*
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism

Substances

Biological Products
Enzyme Inhibitors
PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11