Heparin-Induced Thrombocytopenia: A Review of New Concepts in Pathogenesis, Diagnosis, and Management

Matteo Marchetti; Maxime G Zermatten; Debora Bertaggia Calderara; Alessandro Aliotta; Lorenzo Alberio

doi:10.3390/jcm10040683

Heparin-Induced Thrombocytopenia: A Review of New Concepts in Pathogenesis, Diagnosis, and Management

J Clin Med. 2021 Feb 10;10(4):683. doi: 10.3390/jcm10040683.

Authors

Matteo Marchetti^{1

2}, Maxime G Zermatten¹, Debora Bertaggia Calderara¹, Alessandro Aliotta¹, Lorenzo Alberio¹

Affiliations

¹ Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1011 Lausanne, Switzerland.
² Service de Médecine Interne, Hôpital de Nyon, CH-1260 Nyon, Switzerland.

Abstract

Knowledge on heparin-induced thrombocytopenia keeps increasing. Recent progress on diagnosis and management as well as several discoveries concerning its pathogenesis have been made. However, many aspects of heparin-induced thrombocytopenia remain partly unknown, and exact application of these new insights still need to be addressed. This article reviews the main new concepts in pathogenesis, diagnosis, and management of heparin-induced thrombocytopenia.

Keywords: Bayesian diagnostic thinking; diagnosis; heparin-induced thrombocytopenia (HIT); immune PF4/heparin/antibody complexes; intravenous immunoglobulins (IVIG); management; new concepts; pathogenesis; therapeutic plasma exchange.

Publication types

Review